Basic information of STAT3 :
| Official Symbol of Gene | STAT3 |
| Species | Homo sapiens |
| Entrez Gene ID | 6774 |
| Official Full Name | signal transducer and activator of transcription 3 |
| Also known as | APRF; HIES; ADMIO; ADMIO1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000168610 MIM:102582; AllianceGenome:HGNC:11364 |
| Map Location | 17q21.2 |
Sample information of multiple sclerosis:
| Detected Sample | PBMCs |
| Sample Detail | N/A |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Iranian |
| Sample Size | 51 MS patients / 51 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 31713760 |
| Year | 2019 |
| Title | Differential expression of STAT3 gene and its regulatory long non-coding RNAs, namely lnc-DC and THRIL, in two eastern Iranian ethnicities with multiple sclerosis |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | We were not able to find any significant changes in the expression of STAT3 gene in North Khorasan patients, but it was downregulated in Sistani patients in comparison with their respective healthy controls. |
| Mechanism/Pathway | The JAK/STAT pathway can be activated by a wide range of cytokines and growth factors resulting in the production of some inflammatory mediators.STAT3 is one of the critical members in this signaling pathway that induce the expression of some key genes, including those attributed to inflammation, through its transcriptional factor activity.It seems that JAK/STAT signaling pathway is involved in the pathogenesis of MS through the development of TH17 cells. |
