Basic information of EOMES :

Official Symbol of Gene	EOMES
Species	Homo sapiens
Entrez Gene ID	8320
Official Full Name	eomesodermin
Also known as	TBR2
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000163508 MIM:604615; AllianceGenome:HGNC:3372
Map Location	3p24.1

Sample information of multiple sclerosis:

Detected Sample	peripheral blood mononuclear cells (PBMCs)
Sample Detail	healthy controls (HCs), or patients with either RRMS or SPMS
Detected Method	flow cytometry
Disease	MS
Disease subtype	RRMS or SPMS
Population	N/A
Sample Size	N/A

Literature information of multiple sclerosis :

Pubmed ID	26436530
Year	2015
Title	Eomesodermin-expressing T-helper cells are essential for chronic neuroinflammation

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	Proportions (%) of Eomes+CD4+ T cells among CD4+ T cells in RRMS were not significantly different from HCs,the % of Eomes+ T cells was remarkably increased in patients with SPMS.The increase of Eomes+ cells in SPMS was CD4+ T-cell-specific and was not observed in CD4 T cells .Moreover, proportions of Eomes+CD4+ T cells were further enriched in the CSF from patients with SPMS as compared with corresponding blood samples, indicating their propensity for moving to the site of autoimmune inflammation.These results indicate that Eomes+CD4+ T cells may also play a key pathogenic role in SPMS.
Mechanism/Pathway	N/A