Basic information of CTLA4 :
| Official Symbol of Gene | CTLA4 |
| Species | Homo sapiens |
| Entrez Gene ID | 1493 |
| Official Full Name | cytotoxic T-lymphocyte associated protein 4 |
| Also known as | CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000163599 MIM:123890; AllianceGenome:HGNC:2505 |
| Map Location | 2q33.2 |
Sample information of multiple sclerosis:
| Detected Sample | venous blood |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Polish MS patients |
| Sample Size | n=102 |
Literature information of multiple sclerosis :
| Pubmed ID | 12894875 |
| Year | 2003 |
| Title | Lack of Association between an Exon 1 CTLA-4 Gene Polymorphism A(49)G and Multiple Sclerosis in a Polish Population of the Lower Silesia Region |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | CTLA-4 plays an important role in the downregulation of the early and late stages of T cell activation and the maintenance of peripheral T cell tolerance |
| Mechanism/Pathway | downregulation of the early and late stages of T cell activation |
