Basic information of HLA-DRB1 :
| Official Symbol of Gene | HLA-DRB1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3123 |
| Official Full Name | major histocompatibility complex, class II, DR beta 1 |
| Also known as | SS1; DRB1; HLA-DRB; HLA-DR1B |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000196126 MIM:142857; AllianceGenome:HGNC:4948 |
| Map Location | 6p21.32 |
Sample information of multiple sclerosis:
| Detected Sample | cortical gray matter |
| Sample Detail | N/A |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | UK |
| Sample Size | 64 MS NAGM samples and 42 control gray matter samples |
Literature information of multiple sclerosis :
| Pubmed ID | 31882398 |
| Year | 2020 |
| Title | Increased HLA-DR expression and cortical demyelination in MS links with HLA-DR15 |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Analysis of gray matter lesion size revealed a significant increase of cortical lesion size in cases with high HLA-DRB1 expression. |
| Mechanism/Pathway | Our data indicate that increased HLA-DRB1 and -DRB5 expression in the brain ofpatients with MS may be an important factor in how the HLA-DR15 haplotype contributes to MS pathomechanisms in the target organ. |
