Basic information of CD274 :
| Official Symbol of Gene | CD274 |
| Species | Homo sapiens |
| Entrez Gene ID | 29126 |
| Official Full Name | CD274 molecule |
| Also known as | B7-H; B7H1; PDL1; PD-L1; hPD-L1; PDCD1L1; PDCD1LG1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000120217 MIM:605402; AllianceGenome:HGNC:17635 |
| Map Location | 9p24.1 |
Sample information of multiple sclerosis:
| Detected Sample | whole blood |
| Sample Detail | PBMCs |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Iranian |
| Sample Size | 50 MS and 50 healthy individuals |
Literature information of multiple sclerosis :
| Pubmed ID | 27921410 |
| Year | 2016 |
| Title | Downregulation of Immunosuppressive Molecules, PD-1 and PD-L1 but not PD-L2, in the Patients with Multiple Sclerosis |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | Relative expression of PD-1 and PD-L1 in PBMCs from MS patients was significantly lower compared with the healthy control group (p=0.003 and 0.012, respectively). |
| Mechanism/Pathway | may imply that over-activation of immune cells in multiple sclerosis occurs through signaling dysfunction of these molecules and PD-L2 plays no important role in this context. |
