Basic information of MIR26A1 :
| Official Symbol of Gene | MIR26A1 |
| Species | Homo sapiens |
| Entrez Gene ID | 407015 |
| Official Full Name | microRNA 26a-1 |
| Also known as | MIR26A; MIRN26A1; mir-26a-1 |
| Gene Type | ncRNA |
| dbXrefs | Ensembl:ENSG00000199075 MIM:612151; miRBase:MI0000083; AllianceGenome:HGNC:31610 |
| Map Location | 3p22.2 |
Sample information of multiple sclerosis:
| Detected Sample | blood samples |
| Sample Detail | PBLs |
| Detected Method | RT-PCR,TaqMan assay |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Isfahan |
| Sample Size | 40RRMS 20healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 24792898 |
| Year | 2014 |
| Title | miR-326 and miR-26a, twopotential markers for diagnosis ofrelapse and remission phases in patient with relapsing–remitting multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Similar expression pattern to miR-326 and insilico molecular enrichment analysis altogether suggest an inducing role of miR-26a in differentiation of pathogenic Th17 cells during pathogenesis of multiple sclerosis by targeting major components of the TGF-å°¾ signaling pathway (i.e. SMAD4 and SMAD1) and disarrangement of this signaling pathway. |
| Mechanism/Pathway | f miR-26a in differentiation of pathogenic Th17 cells during pathogenesis of multiple sclerosis by targeting major components of the TGF-å°¾ signaling pathway |
