Basic information of IDO1 :
| Official Symbol of Gene | IDO1 |
| Species | Homo sapiens |
| Entrez Gene ID | 3620 |
| Official Full Name | indoleamine 2,3-dioxygenase 1 |
| Also known as | IDO; INDO; IDO-1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000131203 MIM:147435; AllianceGenome:HGNC:6059 |
| Map Location | 8p11.21 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | PBMCs |
| Detected Method | q-PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 36 relapsing remitting (RR)-MS patients (21 in acute phase -AMS, 15 in stable phase -SMS) and 15 healthy controls (HC) |
Literature information of multiple sclerosis :
| Pubmed ID | 26110930 |
| Year | 2015 |
| Title | Indoleamine 2,3 Dioxygenase (IDO) Expression and Activity in RelapsingRemitting Multiple Sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Measurement of IDO gene expression and activity in blood could be a useful marker to monitor the clinical course of RR-MS. Therapeutic interventions modulating IDO activity may be beneficial in MS |
| Mechanism/Pathway | Glucocorticoids-induced disease remission resulted in a significant reduction of IDO and IFN-纬 gene expression, IDO catalytic activity |
