Basic information of IL7 :
| Official Symbol of Gene | IL7 |
| Species | Homo sapiens |
| Entrez Gene ID | 3574 |
| Official Full Name | interleukin 7 receptor |
| Also known as | IL-7 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000104432 MIM:146660; AllianceGenome:HGNC:6023 |
| Map Location | 8q21.13 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | peripheral blood mononuclear cells cerebrospinal fluid |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | PPMS, RRMS |
| Population | Sweden, Norway, Denmark and Finland |
| Sample Size | 75 individuals with multiple sclerosis 48 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 17660816 |
| Year | 2007 |
| Title | Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulated |
| Risk type | Disease risk |
| Result | IL7 mRNA expression is higher in the CSF of individuals with multiple sclerosis than in the CSF of individuals with other noninflammatory neurological disorders. |
| Mechanism/Pathway | IL7Ra (also known as CD127), encoded by IL7R, is a member of the type I cytokine receptor family and forms a receptor complex with the common cytokine receptor gamma chain (CD132) in which IL7 is the ligand1. |
