Basic information of SIRT1 :
| Official Symbol of Gene | SIRT1 |
| Species | Homo sapiens |
| Entrez Gene ID | 23411 |
| Official Full Name | sirtuin 1 |
| Also known as | SIR2; SIR2L1; SIR2alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000096717 MIM:604479; AllianceGenome:HGNC:14929 |
| Map Location | 10q21.3 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | peripheral blood mononuclear cells |
| Detected Method | real time-PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Sina |
| Sample Size | 12 patients with relapsing–remitting MS (RRMS) and 14 age- and sexmatched healthy subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 26679105 |
| Year | 2016 |
| Title | Evidence for possible role of melatonin in reducing oxidative stress in multiple sclerosis through its effect on SIRT1 and antioxidant enzymes |
Results of multiple sclerosis :
| Expression | up-regulated |
| Risk type | Disease risk |
| Result | Melatonin significantly increased activities and mRNA levels of SIRT1. |
| Mechanism/Pathway | It appears that the antioxidant status is affected in PBMCs from MS patients and melatonin could improve impaired antioxidant defense in MS through up egulation of SIRT1, MnSOD and catalase, which might be important in MS management. |
