Basic information of IKZF2 :
| Official Symbol of Gene | IKZF2 |
| Species | Homo sapiens |
| Entrez Gene ID | 22807 |
| Official Full Name | IKAROS family zinc finger 2 |
| Also known as | ANF1A2; HELIOS; ZNF1A2; ZNFN1A2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000030419 MIM:606234; AllianceGenome:HGNC:13177 |
| Map Location | 2q34 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | PBMCs |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | SPMS |
| Population | Iranic |
| Sample Size | 25 HCs and 25 SPMS patients |
Literature information of multiple sclerosis :
| Pubmed ID | 36738680 |
| Year | 2023 |
| Title | Decreased frequency of regulatory T cells and level of helios gene expression in secondary progressive multiple sclerosis patients: Evidence about the development of multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | a decrease in the frequency of the CD4+CD25+FOXP3+Helios+ Treg population can result in an imbalanced immune system. In other words, one of the immunological mechanisms involved in this disease may be a deficiency in Tregs. Helios gene expression was also decreased in these patients, which may exacerbate functional defects in Tregs. |
| Mechanism/Pathway | a decrease in the frequency of the CD4+CD25+FOXP3+Helios+ Treg population can result in an imbalanced immune system. In other words, one of the immunological mechanisms involved in this disease may be a deficiency in Tregs. Helios gene expression was also decreased in these patients, which may exacerbate functional defects in Tregs. |
