Basic information of NR4A2 :
| Official Symbol of Gene | NR4A2 |
| Species | Homo sapiens |
| Entrez Gene ID | 4929 |
| Official Full Name | nuclear receptor subfamily 4 group A member 2 |
| Also known as | NOT; RNR1; HZF-3; IDLDP; NURR1; TINUR |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000153234 MIM:601828; AllianceGenome:HGNC:7981 |
| Map Location | 2q24.1 |
Sample information of multiple sclerosis:
| Detected Sample | Peripheral blood |
| Sample Detail | N/A |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 45 HCs，66 T0 patients，52 patients with RRMS |
Literature information of multiple sclerosis :
| Pubmed ID | 30565812 |
| Year | 2018 |
| Title | Study of the NR4A family gene expression in patients with multiple sclerosis treated with Fingolimod |
Results of multiple sclerosis :
| Expression | N/A |
| Risk type | Treatment risk |
| Result | Gene expression levels of NR4A were down-regulated in T0 patients compared with HCs. Patients treated with Fingolimod for >2 years were characterized by higher levels of NR4A2 compared with the T0 group, approaching those of HCs. NR4A1 and NR4A3 levels were not altered. |
| Mechanism/Pathway | a role of Fingolimod in the recovery from NR4A2 deficit |
