Basic information of ADRA1A :
| Official Symbol of Gene | ADRA1A |
| Species | Homo sapiens |
| Entrez Gene ID | 148 |
| Official Full Name | adrenoceptor alpha 1A |
| Also known as | ADRA1C; ADRA1L1; ALPHA1AAR |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000120907 MIM:104221; AllianceGenome:HGNC:277 |
| Map Location | 8p21.2 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | PBMCs |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Italian |
| Sample Size | 38 |
Literature information of multiple sclerosis :
| Pubmed ID | 27609280 |
| Year | 2016 |
| Title | Dopaminergic receptors and adrenoceptors in circulating lymphocytes as putative biomarkers for the early onset and progression of multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Expression ofseveral DRandAR are upregulated in PBMC, Teffand Treg from CIS subjects. DRD3 and 伪2A-ARmRNA in PBMC, and DR D5 mRNA in Treg correlate with the risk ofMS at 12 months. Results show the involvement of dopaminergic and adrenergic pathways in CIS as well as in MS pathogenesis, supporting the evaluation of dopaminergic and adrenergic agents in MS. |
| Mechanism/Pathway | the involvement of dopaminergic and adrenergic pathways in CIS as well as in MS pathogenesis |
