Basic information of PLP1 :
| Official Symbol of Gene | PLP1 |
| Species | Homo sapiens |
| Entrez Gene ID | 5354 |
| Official Full Name | proteolipid protein 1 |
| Also known as | PLP; PMD; HLD1; MMPL; SPG2; GPM6C; PLP/DM20 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000123560 MIM:300401; AllianceGenome:HGNC:9086 |
| Map Location | Xq22.2 |
Sample information of multiple sclerosis:
| Detected Sample | serum |
| Sample Detail | PBMCs |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Tranic |
| Sample Size | 30MS |
Literature information of multiple sclerosis :
| Pubmed ID | 27917626 |
| Year | 2016 |
| Title | Association of New Putative Epitopes of Myelin Proteolipid Protein (58-74) with Pathogenesis of Multiple Sclerosis |
Results of multiple sclerosis :
| Expression | positive |
| Risk type | Disease risk |
| Result | PLP58-74 can stimulate CD4+ T cells and humoral immunity. Therefore it seems that the epitopes of some microorganisms mimicking PLP such as PLP58-74 might have a potential role in the initiation of MS. |
| Mechanism/Pathway | self-antigens expressed |
