Basic information of CXCR4 :
| Official Symbol of Gene | CXCR4 |
| Species | Homo sapiens |
| Entrez Gene ID | 7852 |
| Official Full Name | C-X-C motif chemokine receptor 4 |
| Also known as | FB22; HM89; LAP3; LCR1; NPYR; WHIM; CD184; LAP-3; LESTR; NPY3R; NPYRL; WHIMS; HSY3RR; NPYY3R; WHIMS1; D2S201E |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000121966 MIM:162643; AllianceGenome:HGNC:2561 |
| Map Location | 2q22.1 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | WBC |
| Detected Method | Real-time PCR |
| Disease | MS |
| Disease subtype | RRMSã€SPMS |
| Population | individuals with MS |
| Sample Size | RRMS n=32ï¼›SPMS n=22ï¼›controls n=21 |
Literature information of multiple sclerosis :
| Pubmed ID | 27519689 |
| Year | 2016 |
| Title | Identification of gene expression patterns crucially involved in experimental autoimmune encephalomyelitis and multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Upregulation of CXCR4 mRNA was also observed in white blood cells of individuals with MS with a relapsing-remitting disease course and a secondary chronic progressive disease course |
| Mechanism/Pathway | The hereby-defined underlying pathways indicate cellular activation and migration pathways mediated by G-protein-coupled receptors as crucial events in CNS tissue damage |
