Basic information of TIAM1 :
| Official Symbol of Gene | TIAM1 |
| Species | Homo sapiens |
| Entrez Gene ID | 11805 |
| Official Full Name | TIAM Rac1 associated GEF 1 |
| Also known as | NEDLDS; TIAM-1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000156299 MIM:600687; AllianceGenome:HGNC:11805 |
| Map Location | 21q22.11 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | TaqMan PCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | n = 8 (case group)/n = 4 (control group) |
Literature information of multiple sclerosis :
| Pubmed ID | 27725632 |
| Year | 2016 |
| Title | Tiam1/Rac1 complex controls Il17a transcription and autoimmunity |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | we found that the expression of both Tiam1 and Rac1 is significantly higher in Th17 cells differentiated in vitro according to a standard protocol for 7 days. |
| Mechanism/Pathway | we have demonstrated that Tiam1/Rac1 signalling is required for the encephalitogenicity of CD4+ T cells, very likely through its regulation of RORγt-mediated Il17 transcription |
