Details

Home Details


Basic information of CD4 :

Official Symbol of Gene CD4
Species Homo sapiens
Entrez Gene ID 1678
Official Full Name CD4 molecule
Also known as T4; IMD79; Leu-3; OKT4D; CD4mut
Gene Type protein coding
dbXrefs Ensembl:ENSG00000010610 MIM:186940; AllianceGenome:HGNC:1678
Map Location 12p13.31

Sample information of multiple sclerosis:

Detected Sample peripheral blood
Sample Detail N/A
Detected Method RT-PCR
Disease MS
Disease subtype N/A
Population N/A
Sample Size 8 MS cases and 8 controls

Literature information of multiple sclerosis :

Pubmed ID 11086101
Year 2000
Title Transcriptional analysis of multiple sclerosis brain lesions reveals a complex pattern of cytokine expression

Results of multiple sclerosis :

Expression up-regulation
Risk type Disease risk
Result CD4 and HLA-DRalpha transcripts were dramatically increased in MS as compared with controls
Mechanism/Pathway This reveals a robust MHC class II up-regulation and suggests that Ag is being presented locally to activated T cells