Basic information of IL27 :
| Official Symbol of Gene | IL27 |
| Species | Homo sapiens |
| Entrez Gene ID | 246778 |
| Official Full Name | interleukin 27 |
| Also known as | p28; IL30; IL-27; IL27A; IL-27A; IL27p28 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000197272 MIM:608273; AllianceGenome:HGNC:19157 |
| Map Location | 16p12.1-p11.2 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | peripheral blood mononuclear cells |
| Detected Method | Real Time PCR |
| Disease | MS |
| Disease subtype | PPMS, RRMS, SPMS |
| Population | N/A |
| Sample Size | 45 newly-diagnosed MS patients and 45 age- and gender-matched healthy controls |
Literature information of multiple sclerosis :
| Pubmed ID | 25780887 |
| Year | 2015 |
| Title | Cytokines gene expression in newly diagnosed multiple sclerosis patients |
Results of multiple sclerosis :
| Expression | down-regulated |
| Risk type | Disease risk |
| Result | The mRNA mean expressions of IL-17, IL-10, IL-27, TGF-β were different in patient and control groups,which displayed a significant increase in IL-17 and decrease in IL-10, IL-27 and TGF-β in patients group (p=0.015, p=0.005, p=0.027, p<0.001). |
| Mechanism/Pathway | inhibitor cytokines |
