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Basic information of CCL5 :

Official Symbol of Gene CCL5
Species Homo sapiens
Entrez Gene ID 10632
Official Full Name C-C motif chemokine ligand 5
Also known as SISd; eoCP; SCYA5; RANTES; TCP228; D17S136E; SIS-delta
Gene Type protein coding
dbXrefs Ensembl:ENSG00000271503 MIM:187011; AllianceGenome:HGNC:10632
Map Location 17q12

Sample information of multiple sclerosis:

Detected Sample peripheral blood
Sample Detail N/A
Detected Method RT-PCR
Disease MS
Disease subtype N/A
Population N/A
Sample Size 8 MS cases and 8 controls

Literature information of multiple sclerosis :

Pubmed ID 11086101
Year 2000
Title Transcriptional analysis of multiple sclerosis brain lesions reveals a complex pattern of cytokine expression

Results of multiple sclerosis :

Expression up-regulation
Risk type Disease risk
Result Although analysis of cytokine and cytokine receptor genes expression showed predominantly increased levels of several Th1 molecules (TGF-ss, RANTES, and macrophage-inflammatory protein (MIP)-1alpha) in MS samples
Mechanism/Pathway our data suggest a complex regulation of the inflammatory response in human autoimmune demyelination