Basic information of IL12A :
| Official Symbol of Gene | IL12A |
| Species | Homo sapiens |
| Entrez Gene ID | 5969 |
| Official Full Name | interleukin 12A |
| Also known as | P35; CLMF; NFSK; NKSF1; IL-12A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000168811 MIM:161560; AllianceGenome:HGNC:5969 |
| Map Location | 3q25.33 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | TaqMan RT-qPCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 39 MS cases and 39 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 22978757 |
| Year | 2012 |
| Title | Cellular sources of dysregulated cytokines in relapsing-remitting multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | RRMS patients had increased expression of IFN-gamma (IFNG), interleukin (IL) 1-beta (IL1B), IL7, IL10, IL12A, IL15, IL23, IL27, lymphotoxin-alpha (LTA) and lymphotoxin-beta (LTB) in WB |
| Mechanism/Pathway | our findings suggest a pathogenetic role of B-cells and an immunoregulatory role of monocytes in RRMS |
