Basic information of LTA :
| Official Symbol of Gene | LTA |
| Species | Homo sapiens |
| Entrez Gene ID | 6709 |
| Official Full Name | lymphotoxin alpha |
| Also known as | LT; TNFB; TNFSF1; TNLG1E |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000226979 MIM:153440; AllianceGenome:HGNC:6709 |
| Map Location | 6p21.33 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | TaqMan RT-qPCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 39 MS cases and 39 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 22978757 |
| Year | 2012 |
| Title | Cellular sources of dysregulated cytokines in relapsing-remitting multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | RRMS patients had increased expression of IFN-gamma (IFNG), interleukin (IL) 1-beta (IL1B), IL7, IL10, IL12A, IL15, IL23, IL27, lymphotoxin-alpha (LTA) and lymphotoxin-beta (LTB) in WB |
| Mechanism/Pathway | our findings suggest a pathogenetic role of B-cells and an immunoregulatory role of monocytes in RRMS |
