Basic information of A2M :

Official Symbol of Gene	A2M
Species	Homo sapiens
Entrez Gene ID	7
Official Full Name	alpha-2-macroglobulin
Also known as	A2MD; CPAMD5; FWP007; S863-7
Gene Type	protein coding
dbXrefs	Ensembl:ENSG00000175899 MIM:103950; AllianceGenome:HGNC:7
Map Location	12p13.31

Sample information of multiple sclerosis:

Detected Sample	peripheral blood
Sample Detail	N/A
Detected Method	RT-qPCR
Disease	MS
Disease subtype	N/A
Population	N/A
Sample Size	45 MS cases and 45 controls

Literature information of multiple sclerosis :

Pubmed ID	33086557
Year	2020
Title	Increased Pro-Thrombotic Platelet Activity Associated with Thrombin/PAR1-Dependent Pathway Disorder in Patients with Secondary Progressive Multiple Sclerosis

Results of multiple sclerosis :

Expression	up-regulation
Risk type	Disease risk
Result	The mRNA expression of gene coding α2M was upregulated, whilst ApoA1 was down-regulated, both in platelets and megakaryocytes from MS patients
Mechanism/Pathway	the high risk of ischemic events in multiple sclerosis (MS) that are associated with increased pro-thrombotic activity of blood platelets