Basic information of NR1I2 :
| Official Symbol of Gene | NR1I2 |
| Species | Homo sapiens |
| Entrez Gene ID | 7968 |
| Official Full Name | nuclear receptor subfamily 1 group I member 2 |
| Also known as | BXR; PAR; PRR; PXR; SAR; SXR; ONR1; PAR1; PAR2; PARq |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000144852 MIM:603065; AllianceGenome:HGNC:7968 |
| Map Location | 3q13.33 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | RT-qPCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | N/A |
| Sample Size | 45 MS cases and 45 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 33086557 |
| Year | 2020 |
| Title | Increased Pro-Thrombotic Platelet Activity Associated with Thrombin/PAR1-Dependent Pathway Disorder in Patients with Secondary Progressive Multiple Sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Furthermore, we observed an increase in both mRNA expression and surface density of PAR1 in platelets and megakaryocytes in MS compared to controls |
| Mechanism/Pathway | the high risk of ischemic events in multiple sclerosis (MS) that are associated with increased pro-thrombotic activity of blood platelets |
