Basic information of CD86 :
| Official Symbol of Gene | CD86 |
| Species | Homo sapiens |
| Entrez Gene ID | 1705 |
| Official Full Name | CD86 molecule |
| Also known as | B70; B7-2; B7.2; LAB72; CD28LG2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000114013 MIM:601020; AllianceGenome:HGNC:1705 |
| Map Location | 3q13.33 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | RT-qPCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | healthy donors (n = 15), untreated (n = 13), and laquinimod-treated patients with MS (n = 14) |
Literature information of multiple sclerosis :
| Pubmed ID | 33203651 |
| Year | 2020 |
| Title | Laquinimod dampens IL-1β signaling and Th17-polarizing capacity of monocytes in patients with MS |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Laquinimod did not alter the frequency or viability of circulating monocytes, but led to an upregulation of CD86 expression |
| Mechanism/Pathway | laquinimod-associated inhibition of the NF-κB pathway |
