Basic information of IL1B :
| Official Symbol of Gene | IL1B |
| Species | Homo sapiens |
| Entrez Gene ID | 5992 |
| Official Full Name | interleukin 1 beta |
| Also known as | IL-1; IL1F2; IL1beta; IL1-BETA |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000125538 MIM:147720; AllianceGenome:HGNC:5992 |
| Map Location | 2q14.1 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | RT-qPCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | healthy donors (n = 15), untreated (n = 13), and laquinimod-treated patients with MS (n = 14) |
Literature information of multiple sclerosis :
| Pubmed ID | 33203651 |
| Year | 2020 |
| Title | Laquinimod dampens IL-1β signaling and Th17-polarizing capacity of monocytes in patients with MS |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | LPS-stimulated monocytes of laquinimod-treated patients with MS secreted less IL-1β following a downregulation of IL-1β gene expression |
| Mechanism/Pathway | laquinimod-associated inhibition of the NF-κB pathway |
