Basic information of JUN :
| Official Symbol of Gene | JUN |
| Species | Homo sapiens |
| Entrez Gene ID | 6204 |
| Official Full Name | Jun proto-oncogene, AP-1 transcription factor subunit |
| Also known as | AP1; p39; AP-1; cJUN; c-Jun |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000177606 MIM:165160; AllianceGenome:HGNC:6204 |
| Map Location | 1p32.1 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | RT-qPCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 16 MS cases and 28 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 27036414 |
| Year | 2016 |
| Title | Altered molecular expression of TLR-signaling pathways affects the steady-state release of IL-12p70 and IFN-α in patients with relapsing-remitting multiple sclerosis |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | We observed lower relative expression levels of JUN (P = 0.015) and IRF1 (P = 0.006) in circulating cDC from patients with RRMS compared with cDC from healthy controls |
| Mechanism/Pathway | The observed alterations in the gene expression of molecules involved in the TLR4 and TLR7 signaling pathways in circulating DC subsets may underlie the impaired IL-12p70 and IFN-α secretion in patients with RRMS, thereby potentially contributing to the disease pathogenesis of MS |
