Basic information of TLR4 :
| Official Symbol of Gene | TLR4 |
| Species | Homo sapiens |
| Entrez Gene ID | 11850 |
| Official Full Name | toll like receptor 4 |
| Also known as | TOLL; CD284; TLR-4; ARMD10 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000136869 MIM:603030; AllianceGenome:HGNC:11850 |
| Map Location | 9q33.1 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | RT-qPCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 16 MS cases and 28 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 27036414 |
| Year | 2016 |
| Title | Altered molecular expression of TLR-signaling pathways affects the steady-state release of IL-12p70 and IFN-α in patients with relapsing-remitting multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | pDC from patients with RRMS showed an increased relative expression level of TLR4 (P = 0.017) and LY86 (P = 0.020) in comparison with healthy controls |
| Mechanism/Pathway | The observed alterations in the gene expression of molecules involved in the TLR4 and TLR7 signaling pathways in circulating DC subsets may underlie the impaired IL-12p70 and IFN-α secretion in patients with RRMS, thereby potentially contributing to the disease pathogenesis of MS |
