Basic information of LAG3 :
| Official Symbol of Gene | LAG3 |
| Species | Homo sapiens |
| Entrez Gene ID | 6476 |
| Official Full Name | lymphocyte activating 3 |
| Also known as | CD223 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000089692 MIM:153337; AllianceGenome:HGNC:6476 |
| Map Location | 12p13.31 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | RT-qPCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 121 MS cases and 69 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 35022272 |
| Year | 2022 |
| Title | Fewer LAG-3+ T Cells in Relapsing-Remitting Multiple Sclerosis and Type 1 Diabetes |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | In T cells from subjects with RRMS, LAG3 mRNA expression was less than in resting CD4 (median 2.58-fold) and CD8 T cells (2.16-fold) from HC |
| Mechanism/Pathway | The co-inhibitory receptor lymphocyte activation gene 3 (LAG-3) is an immune checkpoint |
