Basic information of CYP27B1 :
| Official Symbol of Gene | CYP27B1 |
| Species | Homo sapiens |
| Entrez Gene ID | 2606 |
| Official Full Name | cytochrome P450 family 27 subfamily B member 1 |
| Also known as | VDR; CP2B; CYP1; PDDR; VDD1; VDDR; VDDRI; CYP27B; P450c1; CYP1alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000111012 MIM:609506; AllianceGenome:HGNC:2606 |
| Map Location | 12q14.1 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | RT-qPCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | n = 23 (case group )/n = 12 (control group) |
Literature information of multiple sclerosis :
| Pubmed ID | 28355272 |
| Year | 2017 |
| Title | Vitamin D receptor gene is epigenetically altered and transcriptionally up-regulated in multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | VDR mRNA levels are upregulated in RRMS patients compared to healthy controls |
| Mechanism/Pathway | On the whole, these results suggest that epigenetic mechanisms may underlie the role that vitamin D plays in MS |
