Basic information of PRKCA :
| Official Symbol of Gene | PRKCA |
| Species | Homo sapiens |
| Entrez Gene ID | 9393 |
| Official Full Name | protein kinase C alpha |
| Also known as | AAG6; PKCA; PRKACA; PKCI+/-; PKCalpha; PKC-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000154229 MIM:176960; AllianceGenome:HGNC:9393 |
| Map Location | 17q24.2 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | N/A |
| Detected Method | RT-qPCR |
| Disease | MS |
| Disease subtype | N/A |
| Population | Italians population |
| Sample Size | n = 409 (case group)/n = 723 (control group) |
Literature information of multiple sclerosis :
| Pubmed ID | 25080502 |
| Year | 2014 |
| Title | Functional variations modulating PRKCA expression and alternative splicing predispose to multiple sclerosis |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | well fitting our observation that MS patients have significantly lower PRKCA mRNA levels in blood |
| Mechanism/Pathway | Since we demonstrated that the protein isoform produced through premature polyadenylation aberrantly localizes to the plasma membrane and/or in cytoplasmic clusters, dysregulated PRKCA 3* inclusion may represent an additional mechanism relevant to MS susceptibility |
