Basic information of TLR4 :
| Official Symbol of Gene | TLR4 |
| Species | Homo sapiens |
| Entrez Gene ID | 7099 |
| Official Full Name | toll like receptor 4 |
| Also known as | TOLL; CD284; TLR-4; ARMD10 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000136869 MIM:603030; AllianceGenome:HGNC:11850 |
| Map Location | 9q33.1 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | NA |
| Sample Size | 20MS/23Control |
Literature information of multiple sclerosis :
| Pubmed ID | 22210239 |
| Year | 2012 |
| Title | Differences in metabolite-detecting, adrenergic, and immune gene expression following moderate exercise in chronic fatigue syndrome, multiple sclerosis and healthy controls |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | MS patients had greater post-exercise increases than controls in β-1 and β-2 adrenergic receptor expression (1.4 ± .27 and 1.3 ± .06 fold increase, respectively, p=.02 and <.001) and greater decreases in TLR4 (p=.02). |
| Mechanism/Pathway | Chronic fatigue syndrome (CFS) and multiple sclerosis (MS) are characterized by debilitating fatigue, yet evaluation of this symptom is subjective. |
