Basic information of CD14 :
| Official Symbol of Gene | CD14 |
| Species | Homo sapiens |
| Entrez Gene ID | 929 |
| Official Full Name | CD14 molecule |
| Also known as | NA |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000170458 MIM:158120; AllianceGenome:HGNC:1628 |
| Map Location | 5q31.3 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | Iranian population |
| Sample Size | 14MS/159Control |
Literature information of multiple sclerosis :
| Pubmed ID | 27819517 |
| Year | 2016 |
| Title | Polymorphisms in CD14 Gene May Modify Soluble CD14 Levels and Represent Risk Factors for Multiple Sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Phenotypic risk |
| Result | In summary, we conclude that CD14-159 and -260 polymorphisms are associated with the risk of MS in Iranian population and affects CD14 promoter activity, thereby regulating CD14 expression. |
| Mechanism/Pathway | Besides the central role of the adaptive immune system, a disturbance of innate immune system is also suggested to be involved in the pathogenesis of multiple sclerosis (MS). |
