Basic information of IL18 :
| Official Symbol of Gene | IL18 |
| Species | Homo sapiens |
| Entrez Gene ID | 3606 |
| Official Full Name | interleukin 18 |
| Also known as | IGIF; IL-18; IL-1g; IL1F4 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000150782 MIM:600953; AllianceGenome:HGNC:5986 |
| Map Location | 11q23.1 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | NA |
| Sample Size | 110MS/110Control |
Literature information of multiple sclerosis :
| Pubmed ID | 31736573 |
| Year | 2019 |
| Title | Interleukin 18 Polymorphisms and its serum level in Patients with Multiple Sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | In this study, we showed the significant higher IL-18 serum level and significant different frequencies of two polymorphisms of IL-18 in MS patients. These results show the important roles of IL-18 in MS pathogenesis. However, more studies are needed to verify our results in larger sample size. |
| Mechanism/Pathway | Multiple sclerosis (MS) is a chronic demyelinating disorder of central nervous system. Although the definite pathogenesis of MS has not been understood, crucial role of environmental and genetic risk factors has been proposed. |
