Basic information of MIR26A1 :
| Official Symbol of Gene | MIR26A1 |
| Species | Homo sapiens |
| Entrez Gene ID | 407015 |
| Official Full Name | microRNA 26a-1 |
| Also known as | MIR26A; MIRN26A1; mir-26a-1 |
| Gene Type | ncRNA |
| dbXrefs | Ensembl:ENSG00000199075 MIM:612151; miRBase:MI0000083; AllianceGenome:HGNC:31610 |
| Map Location | 3p22.2 |
Sample information of multiple sclerosis:
| Detected Sample | serum |
| Sample Detail | NA |
| Detected Method | qPCR |
| Disease | MS |
| Disease subtype | peripheral blood lymphocytes |
| Population | RRMS |
| Sample Size | normal controls (n = 38) or from patients with RRMS (n = 42) and in PBLs from patients with relapsing multiple sclerosis (n = 25) or remitting multiple sclerosis (n = 17). |
Literature information of multiple sclerosis :
| Pubmed ID | 25362566 |
| Year | 2013 |
| Title | MicroRNA-132 suppresses autoimmune encephalomyelitis by inducing cholinergic anti-inflammation: a new Ahr-based exploration |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | miR26a is Downregulated in MS Patients |
| Mechanism/Pathway | Using the EAE model system, in vivo silencing of miR26a was found to result in increased expression of Th17-related cytokines and increased severity of EAE, while overexpression of miR26a was found to result in reduced expression of Th17- related cytokines and a milder form of EAE. |
