Basic information of CDKN1A :
| Official Symbol of Gene | CDKN1A |
| Species | Homo sapiens |
| Entrez Gene ID | 1026 |
| Official Full Name | cyclin dependent kinase inhibitor 1A |
| Also known as | P21; CIP1; SDI1; WAF1; CAP20; CDKN1; MDA-6; p21CIP1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000124762 MIM:116899; AllianceGenome:HGNC:1784 |
| Map Location | 6p21.2 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | RRMS/SPMS/CIS |
| Population | NA |
| Sample Size | 30MS |
Literature information of multiple sclerosis :
| Pubmed ID | 32640422 |
| Year | 2020 |
| Title | Signatures of cell stress and altered bioenergetics in skin fibroblasts from patients with multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | We observed endoplasmic reticulum swelling in MS skin fibroblasts, and increased gene expression of cell stress markers including BIP, ATF4, CHOP, GRP94, P53, and P21. |
| Mechanism/Pathway | Multiple sclerosis (MS) is a central nervous system inflammatory demyelinating disease and the most common cause of non-traumatic disability in young adults. |
