Basic information of SOD1 :
| Official Symbol of Gene | SOD1 |
| Species | Homo sapiens |
| Entrez Gene ID | 6647 |
| Official Full Name | superoxide dismutase 1 |
| Also known as | ALS; SOD; ALS1; IPOA; STAHP; hSod1; HEL-S-44; homodimer |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000142168 MIM:147450; AllianceGenome:HGNC:11179 |
| Map Location | 21q22.11 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | real-time PCR. |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Iranian origin |
| Sample Size | 29 cases and 15 controls |
Literature information of multiple sclerosis :
| Pubmed ID | 33354282 |
| Year | 2020 |
| Title | Redox Imbalance in CD4+ T Cells of Relapsing-Remitting Multiple Sclerosis Patients |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Furthermore, the catalase expression augmented in patients at the acute phase (P value < 0.05), while an increased expression of SOD1 and Nrf2 was found in RRMS patients at relapse and remission phases (P value < 0.05). |
| Mechanism/Pathway | As a prevalent autoimmune disease of the central nervous system in young adults, multiple sclerosis (MS) is mediated by T cells,particularly CD4+ subsets. Given the evidence that the perturbation in reactive oxygen species (ROS) production has a pivotal role in the onset and progression of MS, its regulation through the antioxidant molecules is too important. |
