Basic information of MPO :
| Official Symbol of Gene | MPO |
| Species | Homo sapiens |
| Entrez Gene ID | 4353 |
| Official Full Name | myeloperoxidase |
| Also known as | NA |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000005381 MIM:606989; AllianceGenome:HGNC:7218 |
| Map Location | 17q22 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | microgliar/macrophages |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | NA |
| Sample Size | NA |
Literature information of multiple sclerosis :
| Pubmed ID | 9307233 |
| Year | 1997 |
| Title | Immunohistochemical and genetic evidence of myeloperoxidase involvement in multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | This is the first evidence that MPO is present in microgliarmacrophages at MS lesions, that MPO gene expression occurs in microglia and that MPO plays a role in MS pathogenesis as shown by the allelic disequilibrium in early onset disease. |
| Mechanism/Pathway | The myeloperoxidase enzyme MPO is expressed specifically in myeloid cells and catalyzes the formation of hypochlorous acid and other cytotoxic oxidants. |
