Basic information of IL-35 :
| Official Symbol of Gene | IL-35 |
| Species | Homo sapiens |
| Entrez Gene ID | 22163 |
| Official Full Name | tumor necrosis factor receptor superfamily, member 4 |
| Also known as | Ox40; ACT35; CD134; Ly-70; Txgp1; TXGP1L |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSMUSG00000029075 AllianceGenome:MGI:104512 |
| Map Location | 4 E2; 4 87.68 cM |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | serum |
| Detected Method | Real Time-PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | N/A |
| Sample Size | 100 patients with relapsing-remitting multiple sclerosis (RRMS) and 90 healthy subjects |
Literature information of multiple sclerosis :
| Pubmed ID | 32988630 |
| Year | 2021 |
| Title | FOXP3rs3761548 gene variant and interleukin-35 serum levels as biomarkers in patients with multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulated |
| Risk type | Disease risk |
| Result | The serum IL-35 level was significantly higher in MS patients (1372 [575–2192] pg/mL) compared to healthy controls. |
| Mechanism/Pathway | Interleukin-35 (IL-35) is an important immunosuppressive cytokine |
