Basic information of STAT5A :
| Official Symbol of Gene | STAT5A |
| Species | Homo sapiens |
| Entrez Gene ID | 6776 |
| Official Full Name | signal transducer and activator of transcription 5A |
| Also known as | MGF; STAT5 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000126561 MIM:601511; AllianceGenome:HGNC:11366 |
| Map Location | 17q21.2 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | Quantitative real time PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | NA |
| Sample Size | 50MS/50Health |
Literature information of multiple sclerosis :
| Pubmed ID | 29126764 |
| Year | 2018 |
| Title | STAT5a and STAT6 gene expression levels in multiple sclerosis patients |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | We found that STAT5a expression was significantly down-regulated (p = .049), whereas STAT6 gene expression was significantly up-regulated (p = .046) in MS patients compared with controls. |
| Mechanism/Pathway | Cytokines have an important role in inflammation as characteristic feature of the disease. Janus kinase/signal transducers and activators of transcriptions (JAK/STAT) family promote cytokine-mediated cell activation. |
