Basic information of PPARGC1A :
| Official Symbol of Gene | PPARGC1A |
| Species | Homo sapiens |
| Entrez Gene ID | 10891 |
| Official Full Name | PPARG coactivator 1 alpha |
| Also known as | LEM6; PGC1; PGC1A; PGC-1v; PPARGC1; PGC-1alpha; PGC-1(alpha) |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000109819 MIM:604517; AllianceGenome:HGNC:9237 |
| Map Location | 4p15.2 |
Sample information of multiple sclerosis:
| Detected Sample | Brain |
| Sample Detail | NA |
| Detected Method | Real-time quantitative PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | NA |
| Sample Size | 15MS/9Health |
Literature information of multiple sclerosis :
| Pubmed ID | 23073717 |
| Year | 2013 |
| Title | Reduced expression of PGC-1a partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | Taken together, our data indicate that reduced neuronal PGC-1a expression in MS cortex partly underlies mitochondrial dysfunction in MS grey matter and thereby contributes to neurodegeneration in MS cortex. |
| Mechanism/Pathway | There is growing evidence that mitochondrial dysfunction and associated reactive oxygen species (ROS)formation contribute to neurodegenerative processes in multiple sclerosis (MS). |
