Basic information of SP3 :
| Official Symbol of Gene | SP3 |
| Species | Homo sapiens |
| Entrez Gene ID | 6670 |
| Official Full Name | Sp3 transcription factor |
| Also known as | SPR2 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000172845 MIM:601804; AllianceGenome:HGNC:11208 |
| Map Location | 2q31.1 |
Sample information of multiple sclerosis:
| Detected Sample | PBMC |
| Sample Detail | NA |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | NA |
| Sample Size | NA |
Literature information of multiple sclerosis :
| Pubmed ID | 12218073 |
| Year | 2002 |
| Title | Sp3 Expression in Immune Cells: A Quantitative Study |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | We propose that transcription of the Sp3 gene is blocked in immune cells from most patients with MS and that this contributes to the development of central nervous system inflammation in the disease. |
| Mechanism/Pathway | We previously reported the lack of expression of the bifunctional transcription factor Sp3 in peripheral blood mononuclear cells from most patients with multiple sclerosis (MS) |
