Basic information of PTPN6 :
| Official Symbol of Gene | PTPN6 |
| Species | Homo sapiens |
| Entrez Gene ID | 5777 |
| Official Full Name | protein tyrosine phosphatase non-receptor type 6 |
| Also known as | HCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000111679 MIM:176883; AllianceGenome:HGNC:9658 |
| Map Location | 12p13.31 |
Sample information of multiple sclerosis:
| Detected Sample | Brain |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | NA |
| Sample Size | NA |
Literature information of multiple sclerosis :
| Pubmed ID | 25919645 |
| Year | 2015 |
| Title | The control of reactive oxygen species production by SHP-1 in oligodendrocytes |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Disease risk |
| Result | Furthermore, we demonstrate that SHP-1 is expressed in human white matter oligodendrocytes and there is a subset of multiple sclerosis (MS) subjects that demonstrate a deficiency of SHP-1 in normal appearing white matter (NAWM). |
| Mechanism/Pathway | We have previously described reduced myelination and corresponding myelin basic protein (MBP) expression in the CNS of Src homology 2 domain-containing protein tyrosine phosphatase 1 (SHP-1) deficient motheaten (me/me) mice compared to normal littermate controls. |
