Basic information of STAT6 :
| Official Symbol of Gene | STAT6 |
| Species | Homo sapiens |
| Entrez Gene ID | 6778 |
| Official Full Name | signal transducer and activator of transcription 6 |
| Also known as | STAT6B; STAT6C; D12S1644; IL-4-STAT |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000166888 MIM:601512; AllianceGenome:HGNC:11368 |
| Map Location | 12q13.3 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | Macrophages |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | MS |
| Population | NA |
| Sample Size | NA |
Literature information of multiple sclerosis :
| Pubmed ID | 19398961 |
| Year | 2009 |
| Title | Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | In conclusion, macrophages of MS patients display a deficiency of SHP-1 expression, heightened activation of STAT6, STAT1, and NF-κB and a corresponding inflammatory profile that may be important in controlling macrophage-mediated demyelination in MS. |
| Mechanism/Pathway | Recent studies in mice have demonstrated that the protein tyrosine phosphatase SHP-1 is a crucial negative regulator of pro-inflammatory cytokine signaling, TLR signaling, and inflammatory gene expression |
