Basic information of TNF :
| Official Symbol of Gene | TNF |
| Species | Homo sapiens |
| Entrez Gene ID | 7124 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892 |
| Map Location | 6p21.33 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS/PPMS/SPMS |
| Population | Caucasian and of Northern Irish |
| Sample Size | 189MS/206Control |
Literature information of multiple sclerosis :
| Pubmed ID | 10408716 |
| Year | 1999 |
| Title | Relationship between tumour necrosis factor-alpha (TNFa) production and a specific multiple sclerosis (MS) associated TNF gene haplotype |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Phenotypic risk |
| Result | We conclude that whilst a trend exists, we have found no significant association between peripheral TNFa production and a specific MS associated TNF haplotype in this population. Paradoxically this haplotype may also predict a more favourable clinical course |
| Mechanism/Pathway | To determine if monocyte TNFa production from patients homozygous for a specific MS associated TNF gene haplotype is different from that produced in patients either heterozygous for, or without this haplotype. |
