Basic information of SERPINE1 :
| Official Symbol of Gene | SERPINE1 |
| Species | Homo sapiens |
| Entrez Gene ID | 5054 |
| Official Full Name | serpin family E member 1 |
| Also known as | PAI; PAI1; PAI-1; PLANH1 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000106366 MIM:173360; AllianceGenome:HGNC:8583 |
| Map Location | 7q22.1 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS/SPMS |
| Population | Mexican mestizo |
| Sample Size | 200MS/200Control |
Literature information of multiple sclerosis :
| Pubmed ID | 31687051 |
| Year | 2019 |
| Title | Association between the -844 G>A, HindIII C>G, and 4G/5G PAI-1 Polymorphisms and Susceptibility to Multiple Sclerosis in Western Mexican Population |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | A significant association was found between the CG genotype of the HindIII C>G PAI-1 polymorphism and susceptibility to MS (OR = 1:58, p = 0:03); moreover, the frequency of 5G allele and 5G/5G genotype of the 4G/5G PAI-1 polymorphism was statistically significant (OR = 1:36 and p = 0:04 and OR = 2:43 and p = 0:02, respectively). |
| Mechanism/Pathway | Tissue plasminogen activator (tPA) is a serine protease that enhances the conversion of plasminogen into its active form plasmin, the principal tPA inhibitor is the PAI-1. |
