Basic information of TNF :
| Official Symbol of Gene | TNF |
| Species | Homo sapiens |
| Entrez Gene ID | 7124 |
| Official Full Name | tumor necrosis factor |
| Also known as | DIF; TNFA; TNFSF2; TNLG1F; TNF-alpha |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000232810 MIM:191160; AllianceGenome:HGNC:11892 |
| Map Location | 6p21.33 |
Sample information of multiple sclerosis:
| Detected Sample | PBMC |
| Sample Detail | NA |
| Detected Method | real-time PCR. |
| Disease | MS |
| Disease subtype | RRMS/PPMS/SPMS |
| Population | NA |
| Sample Size | 191MS/200Control |
Literature information of multiple sclerosis :
| Pubmed ID | 24098530 |
| Year | 2013 |
| Title | Adipocytokine Profile, Cytokine Levels and Foxp3 Expression in Multiple Sclerosis: a Possible Link to Susceptibility and Clinical Course of Disease |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Phenotypic risk |
| Result | In controls, there were positive correlations between circulating leptin and resistin with TNF-α and IL-1β in subgroup analysis, the highest levels of TNF-α, IL-1β, hs-CRP, resistin and leptin were observed in primary progressive-MS (PP-MS) patients. |
| Mechanism/Pathway | Adipocytokines may be involved in multiple sclerosis (MS) as well as other autoimmune and inflammatory-related diseases. |
