Basic information of TNFSF15 :
| Official Symbol of Gene | TNFSF15 |
| Species | Homo sapiens |
| Entrez Gene ID | 9966 |
| Official Full Name | TNF superfamily member 15 |
| Also known as | TL1; TL1A; VEGI; TNLG1B; VEGI192A |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000181634 MIM:604052; AllianceGenome:HGNC:11931 |
| Map Location | 9q32 |
Sample information of multiple sclerosis:
| Detected Sample | PBMC |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS/PPMS/SPMS |
| Population | NA |
| Sample Size | 58MS/16Control |
Literature information of multiple sclerosis :
| Pubmed ID | 31445379 |
| Year | 2019 |
| Title | Gene expression profiles of TNF-like cytokine 1A (TL1A) and its receptors death receptor 3 (DR3) and decoy receptor 3 (DcR3) in multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | Taken together, these findings suggest the TL1A should be evaluated further for its potential as a candidate biomarker of inflammatory activity and the marker of therapeutic response to immunomodulatory treatments in MS. |
| Mechanism/Pathway | TL1A/DR3/DcR3 pathway is an important mediator of inflammatory responses and contributes to the pathogenesis of several chronic inflammatory diseases. |
