Basic information of FOXP3 :
| Official Symbol of Gene | FOXP3 |
| Species | Homo sapiens |
| Entrez Gene ID | 50943 |
| Official Full Name | forkhead box P3 |
| Also known as | JM2; AIID; IPEX; PIDX; XPID; DIETER |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000049768 MIM:300292; AllianceGenome:HGNC:6106 |
| Map Location | Xp11.23 |
Sample information of multiple sclerosis:
| Detected Sample | blood |
| Sample Detail | N/A |
| Detected Method | real-time RT-PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | Russia |
| Sample Size | 52 patients and 22 persons |
Literature information of multiple sclerosis :
| Pubmed ID | 27424664 |
| Year | 2016 |
| Title | Ex vivo expanded regulatory T cells CD4+CD25+FoxP3+CD127Low develop strong immunosuppressive activity in patients with remitting-relapsing multiple sclerosis |
Results of multiple sclerosis :
| Expression | up-regulated |
| Risk type | Disease risk |
| Result | Increased expression of FoxP3 and Helios in expanded Tregs of HD and MS patients |
| Mechanism/Pathway | Tregs differentiation is driven by the transcription factor FoxP3 |
