Basic information of IFNAR2 :
| Official Symbol of Gene | IFNAR2 |
| Species | Homo sapiens |
| Entrez Gene ID | 3455 |
| Official Full Name | interferon alpha and beta receptor subunit 2 |
| Also known as | IFN-R; IMD45; IFNABR; IFNARB; IFN-R-2; IFN-alpha-REC |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000159110 MIM:602376; AllianceGenome:HGNC:5433 |
| Map Location | 21q22.11 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | NA |
| Sample Size | 94MS/41Control |
Literature information of multiple sclerosis :
| Pubmed ID | 34975865 |
| Year | 2021 |
| Title | Soluble Receptor Isoform of IFN-Beta (sIFNAR2) in Multiple Sclerosis Patients and Their Association With the Clinical Response to IFN-Beta Treatment |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Treatment risk |
| Result | IFN-b administration induces the production of sIFNAR2 in RRMS and higher levels might be associated to the reduction of therapeutic response. Thus, levels of sIFNAR2 could be monitored to optimize an effective response to IFN-b therapy. |
| Mechanism/Pathway | Interferon beta receptor 2 subunit (IFNAR2) can be produced as a transmembrane protein, but also as a soluble form (sIFNAR2) generated by alternative splicing or proteolytic cleavage, which has both agonist and antagonist activities for IFN-b. |
