Basic information of LAG3 :
| Official Symbol of Gene | LAG3 |
| Species | Homo sapiens |
| Entrez Gene ID | 3902 |
| Official Full Name | lymphocyte activating 3 |
| Also known as | CD223 |
| Gene Type | protein coding |
| dbXrefs | Ensembl:ENSG00000089692 MIM:153337; AllianceGenome:HGNC:6476 |
| Map Location | 12p13.31 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | real-time PCR. |
| Disease | MS |
| Disease subtype | RRMS/SPMS |
| Population | NA |
| Sample Size | 57MS/19Control |
Literature information of multiple sclerosis :
| Pubmed ID | 31134049 |
| Year | 2019 |
| Title | Blood Levels of Co-inhibitory-Receptors: A Biomarker of Disease Prognosis in Multiple Sclerosis |
Results of multiple sclerosis :
| Expression | up-regulation |
| Risk type | Disease risk |
| Result | This is an initial exploration of the utility of CTLA-4, PD-1, TIM-3, LAG-3,and TIGIT expression levels as prognostic indicators in untreated, recently diagnosed multiple sclerosis. |
| Mechanism/Pathway | The clinical course of multiple sclerosis ranges from benign with little disease progression and minimal disability, to severe disease requiring intensive medical treatment. |
