Basic information of MIR29B1 :
| Official Symbol of Gene | MIR29B1 |
| Species | Homo sapiens |
| Entrez Gene ID | 407024 |
| Official Full Name | microRNA 29b-1 |
| Also known as | miR-29b; MIRN29B1; miRNA29B1; mir-29b-1 |
| Gene Type | ncRNA |
| dbXrefs | Ensembl:ENSG00000283797 MIM:610783; miRBase:MI0000105; AllianceGenome:HGNC:31619 |
| Map Location | 7q32.3 |
Sample information of multiple sclerosis:
| Detected Sample | peripheral blood |
| Sample Detail | NA |
| Detected Method | RT-PCR |
| Disease | MS |
| Disease subtype | RRMS |
| Population | NA |
| Sample Size | 70MS |
Literature information of multiple sclerosis :
| Pubmed ID | 31421628 |
| Year | 2019 |
| Title | MicroRNA-29b variants and MxA expression change during interferon beta therapy in patients with relapsing-remitting multiple sclerosis |
Results of multiple sclerosis :
| Expression | down-regulation |
| Risk type | Treatment risk |
| Result | Our results might provide fundamentals for the development of new markers of the biological effects of IFN-β therapy |
| Mechanism/Pathway | Myelin-reactive IFN-γ-producing Th1 cells has been shown to play an important role in the development of MS. MicroRNAs (miRNAs) are a new class of small non-coding RNA molecules about 22 nucleotides long which regulate gene expression post-tran-scriptionally by binding to 3′ UTR of their mRNA targets, and resulting in degradation or transcriptional re-pression of the targeted mRNA. |
